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Title: Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response.
identifier: 1943980
description:
epitope description:LVSRSLKMRGQAF
antigen name:Other Oryctolagus cuniculus (rabbit) protein
host organism:Oryctolagus cuniculus New Zealand White
aggregation:
instance of dataset
availability:
available
primaryPublications: 14988508
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1024910
landingPage: http://www.iedb.org/assay/1943980
type:
Literature
publicationVenue:
Proc Natl Acad Sci U S A
dates:
2004
study type: b cell assays
subject species: Oryctolagus cuniculus
fullName:
Micah T McClain
Carol S Lutz
Kenneth M Kaufman
Ofer Z Faig
Timothy F Gross
Judith A James
method:
in vivo assay
name:
Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response.
description:
Rabbits immunized with the epitope developed symptoms common to systemic lupus erythematosus by 4 months after initial immunization. These included renal toxicity, as measured by serum creatinine levels, leukopenia and thrombocytopenia.

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