Structural basis of C-terminal beta-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease.

Title:

Structural basis of C-terminal beta-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease.

identifier:	1945025
description:	epitope description:LVFFAEDVGSNKGAIIGAMVGGVV host organism:Mus musculus antibody name:ponezumab
aggregation:	instance of dataset
availability:	available
primaryPublications:	22197375

study type:	b cell assays
subject species:

fullName:	Sherry L La Porte Sangeetha Subbarao Bollini Thomas A Lanz Yasmina N Abdiche Alexander S Rusnak Wei-Hsien Ho Dione Kobayashi Ons Harrabi Danielle Pappas Erene W Mina Anthony J Milici Thomas T Kawabe Kelly Bales John C Lin Jaume Pons

method:	surface plasmon resonance (SPR)

name:	Structural basis of C-terminal beta-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease.
description:	Ponezumab Fab, specific for Aß 30-40, bound to the epitope with substitution L34A in Aß17-40 with 2-fold weaker affinity compared to the wild type sequence.

name:	iedb
homePage:	http://www.iedb.org

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