Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Abeta peptides.

Title:

Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Abeta peptides.

identifier:	1955220
description:	epitope description:DAEFRHD antigen name:Amyloid beta A4 protein host organism:Mus musculus BALB/c antibody name:mC99(1-7)
aggregation:	instance of dataset
availability:	available
primaryPublications:	22317957

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Jemila Houacine Tristan Bolmont Lorè ne Aeschbach Mustapha Oulad-Abdelghani Patrick C Fraering

method:	immuno staining

name:	Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Abeta peptides.
description:	The epitope-specific mAb recognized the antigen in brain sections of human Alzheimer tissue. Strong immunolabeling of A beta plaques was seen. Three-dimensional reconstruction of confocal microscopy images unequivocally revealed the presence of intracellular mAb-positive puncta, thus sustaining their internalization. EM analysis of immunogold-labeled mC99(1–7) in pretreated HEK cells confirmed the localization of these mAbs in multivesicular bodies.

name:	iedb
homePage:	http://www.iedb.org

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