Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1955444 |
| description: |
epitope description:S117, R118, S119, Y120, T122, S123, H124, G125, D126, R128, D129, H172, K200, K201, K202, Q203, Y249, R312, W313
antigen name:Trans-sialidase, putative (UniProt:K4DNS9)
host organism:Mus musculus C3H/He
antibody name:13G9
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
22241998 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025003 |
| landingPage: |
http://www.iedb.org/assay/1955444 |
| type: |
Literature
|
| publicationVenue: |
PLoS Pathog
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Trypanosoma cruzi |
| fullName: |
Alejandro Buschiazzo
Romina Muiá
Nicole Larrieux
Tamara Pitcovsky
Juan Mucci
Oscar Campetella
|
| method: |
biological activity
|
| name: |
Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors.
|
| description: |
The epitope-specific mAb 13G9 neutralized the activity of T. cruzi trans-sialidase. The Fab 13G9 exhibited a lower inhibition potency against the trans-sialidase activity compared to the intact mAb. MAb 13G9 recognized the active trans-sialidase and the inactive trans-sialidase form with a single Tyr342 mutation. MAb 13G9 inhibited the ability of trans-sialidase to transfer sialic acid to trypomastigotes in vitro.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
