Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1955490 |
| description: |
epitope description:R108, N109, V110, G111, S112, Q113, L115, N180, I185, N189, S236, S237, R239, P240, G241, I242, L244, W245, H246
antigen name:Integrin alpha-IIb
host organism:Mus musculus BALB/c
antibody name:10E5
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
22422993 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025006 |
| landingPage: |
http://www.iedb.org/assay/1955490 |
| type: |
Literature
|
| publicationVenue: |
Sci Transl Med
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Jieqing Zhu
Won-Seok Choi
Joshua G McCoy
Ana Negri
Jianghai Zhu
Sarasija Naini
Jihong Li
Min Shen
Wenwei Huang
Daniel Bougie
Mark Rasmussen
Richard Aster
Craig J Thomas
Marta Filizola
Timothy A Springer
Barry S Coller
|
| method: |
x-ray crystallography
|
| name: |
Structure-guided design of a high-affinity platelet integrin alphaIIbbeta3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.
|
| description: |
The epitope of Fab 10E5 on integrin alphaIIbß3 was determined from the crystal structure of the complex. Fab 10E5 binds solely to the alphaIIb cap subdomain and has no effect on its conformation. The inhibitor RUC-2 in 1 mM Ca2+ and 5 mM Mg 2+ was soaked into crystals of the soluble headpiece of integrin alphaIIbbeta3.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
