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Title: Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.
identifier: 1954011
description:
epitope description:K540, R541, S542, G543, Y544, G545, Q546, I548, L586, W587, T647, N648
antigen name:Spike glycoprotein
host organism:Mus musculus BALB/c
antibody name:1AF10
aggregation:
instance of dataset
availability:
available
primaryPublications: 22876187
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1025034
landingPage: http://www.iedb.org/assay/1954011
type:
Literature
publicationVenue:
PLoS Pathog
dates:
2012
study type: b cell assays
subject species: TGEV virulent Purdue
fullName:
Juan Reguera
Cé
sar Santiago
Gaurav Mudgal
Desiderio Ordoñ
o
Luis Enjuanes
José
M Casasnovas
method:
biological activity
name:
Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.
description:
The epitope-specific mAb Fab 1AF10 inhibits the binding of the TGEV spike protein A fragment containing the receptor binding domain (RBD) to pAPN (aminopeptidase N) expressed on BHK cells.

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