Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.

Title:

Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.

identifier:	1954015
description:	epitope description:G543, L586, W587, D588, T647, N648 antigen name:Spike glycoprotein host organism:Mus musculus BALB/c antibody name:1DE7
aggregation:	instance of dataset
availability:	available
primaryPublications:	22876187

study type:	b cell assays
subject species:	TGEV virulent Purdue

fullName:	Juan Reguera Cé sar Santiago Gaurav Mudgal Desiderio Ordoñ o Luis Enjuanes José M Casasnovas

method:	ELISA

name:	Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.
description:	The epitope of mAb 1DE7 bound to the TGEV spike protein A fragment containing the receptor binding domain (RBD) was determined by analysis of binding to RBD mutants. RBD mutations G527D, W571, LWD572A, or TN632AA abolished or greatly reduced binding to the antibody. The mAb 11DE7 recognizes the Ab antigenic subsite.

name:	iedb
homePage:	http://www.iedb.org

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