Residues involved in the antigenic sites of transmissible gastroenteritis coronavirus S glycoprotein.

Title:

Residues involved in the antigenic sites of transmissible gastroenteritis coronavirus S glycoprotein.

identifier:	1954500
description:	epitope description:G543 antigen name:Spike glycoprotein host organism:Mus musculus BALB/c antibody name:1B.B5, 6A.C3, 1A.F10
aggregation:	instance of dataset
availability:	available
primaryPublications:	1711257

study type:	b cell assays
subject species:	Transmissible gastroenteritis virus MAD88

fullName:	F Gebauer W P Posthumus I Correa C Suñ é C Smerdou C M Sá nchez J A Lenstra R H Meloen L Enjuanes

method:	biological activity

name:	Residues involved in the antigenic sites of transmissible gastroenteritis coronavirus S glycoprotein.
description:	The epitopic residues recognized by the antigenic Ac site-specific mAbs 1B.B5 (IgG2b), 6A.C3 (IgG1) and 1A.F10 (IgG1) were determined by sequence analysis of mAb resistant (mar) TGEV mutants selected with neutralizing mAbs. TGEV PUR46 virus Mar mutant with substitution G543D were no longer neutralized by the mAbs. All escape mutants selected by mAb 1B.B5 had an additional change at V631.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.