Residues involved in the antigenic sites of transmissible gastroenteritis coronavirus S glycoprotein.

Title:

Residues involved in the antigenic sites of transmissible gastroenteritis coronavirus S glycoprotein.

identifier:	1954521
description:	epitope description:R591, D586 antigen name:Spike glycoprotein host organism:Mus musculus BALB/c antibody name:1D.E8, 1D.E7, 1H.D2
aggregation:	instance of dataset
availability:	available
primaryPublications:	1711257

study type:	b cell assays
subject species:	Transmissible gastroenteritis virus MAD88

fullName:	F Gebauer W P Posthumus I Correa C Suñ é C Smerdou C M Sá nchez J A Lenstra R H Meloen L Enjuanes

method:	radio immuno assay (RIA)

name:	Residues involved in the antigenic sites of transmissible gastroenteritis coronavirus S glycoprotein.
description:	The epitopic residues recognized by the antigenic Ab site-specific mAbs 1D.E8, 1D.E7 (IgG1), and 1H.D2 (IgG2a) were determined by sequence analysis of mAb resistant (mar) TGEV PUR46 mutants selected with neutralizing mAbs. Mar mutants with substitution D586N or R591Q or R591P were no longer bound by mAbs 1D.E8 and 1D.E, and 1H.D2 was sensitive to mutation at R591.

name:	iedb
homePage:	http://www.iedb.org

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