Residues involved in the antigenic sites of transmissible gastroenteritis coronavirus S glycoprotein.

Title:

Residues involved in the antigenic sites of transmissible gastroenteritis coronavirus S glycoprotein.

identifier:	1954586
description:	epitope description:PPNSDV antigen name:Spike glycoprotein host organism:Mus musculus BALB/c antibody name:6A.A6, 5B.H1
aggregation:	instance of dataset
availability:	available
primaryPublications:	1711257

study type:	b cell assays
subject species:	Transmissible gastroenteritis virus MAD88

fullName:	F Gebauer W P Posthumus I Correa C Suñ é C Smerdou C M Sá nchez J A Lenstra R H Meloen L Enjuanes

method:	ELISA

name:	Residues involved in the antigenic sites of transmissible gastroenteritis coronavirus S glycoprotein.
description:	The epitope recognized by mAbs 6A.A6 (IgG1) and 5B.H1 (IgG2a) was deduced based on analysis of overlapping nonapeptides. The mAbs bound to peptides spanning residues 44-57, and bound strongly to nonapeptides with the sequence PPNSDV. The mAbs bound much more weakly to peptides spanning residues 160-173 (FPICPSNSEANCCN). The author propose that the mAbs recognize a core motif sequence of P-P/S-N/H-S-D/E-V/A.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.