Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1006178 |
| landingPage: |
http://www.iedb.org/assay/1961157 |
| type: |
Literature
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| publicationVenue: |
Infect Immun
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| dates: |
2005
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| study type: | b cell assays |
| subject species: | Streptococcus mutans |
| fullName: |
Daniel J Smith
William F King
Joy Rivero
Martin A Taubman
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| method: |
in vivo assay
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| name: |
Immunological and protective effects of diepitopic subunit dental caries vaccines.
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| description: |
This sequence is stated to be identical to residues 442-464 from the S. mutans GbpB protein and residues 444-466 of the S. sobrinus GTF-I protein. The sequence is instead found in GTF-I protein (gtfB gene) of S. mutans but not on published GbpB sequences. The sequence shown in the manuscript differs from the natural sequence shown in the cited reference (Infect Immun. 1994 62(12):5470 [PMID:7960128]) as the sequence source, so the natural sequence is curated here.
Rats were then orally infected with 10^8 streptomycin-resistant S. mutans strain SJ32 cells for 3 consecutive days. After 64 days of S. mutans infection, dental caries on buccal, lingual and occlusal molar surfaces were evaluated. Rats immunized with the epitope CAT demonstrated lower caries scores. Addition of a second streptoccocus epitope did not affect the results.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
