Cross-neutralization of influenza A viruses mediated by a single antibody loop. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Cross-neutralization of influenza A viruses mediated by a single antibody loop.

Dataset

identifier:	1959014
description:	epitope description:Y114, T147, N149, G150, G151, S152, N153, S161, W169, T171, K172, Q205, E206, T208, S209, L210, L242 antigen name:Hemagglutinin host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	22982990

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025144
landingPage:	http://www.iedb.org/assay/1959014

Publication

type:	Literature
publicationVenue:	Nature
dates:	2012

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/Hong Kong/1/1968(H3N2))

Person

fullName:	Damian C Ekiert Arun K Kashyap John Steel Adam Rubrum Gira Bhabha Reza Khayat Jeong Hyun Lee Michael A Dillon Ryann E O'Neil Aleksandr M Faynboym Michael Horowitz Lawrence Horowitz Andrew B Ward Peter Palese Richard Webby Richard A Lerner Ramesh R Bhatt Ian A Wilson

Data Type

method:	in vivo assay

Study

name:	Cross-neutralization of influenza A viruses mediated by a single antibody loop.
description:	Administration of 25 mg/kg mAb C05 before challenge with A/Aichi/2/X-31/1968 (H3N2) protected 100% of mice from death and prevented substantial weight loss. Mice treated therapeutically with a single dose of 15 mg/kg C05 up to 3 days after infection were protected.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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