Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.

Title:

Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.

Dataset

identifier:	1958889
description:	epitope description:NTGWLAGLFYQHK antigen name:Genome polyprotein host organism:Homo sapiens antibody name:HC-84.1, HC-84.25, HC-84.26, HC-84.27
aggregation:	instance of dataset
availability:	available
primaryPublications:	22511875

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1023047
landingPage:	http://www.iedb.org/assay/1958889

Publication

type:	Literature
publicationVenue:	PLoS Pathog
dates:	2012

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

Person

fullName:	Zhen-yong Keck Jinming Xia Yong Wang Wenyan Wang Thomas Krey Jannick Prentoe Thomas Carlsen Angela Ying-Jian Li Arvind H Patel Stanley M Lemon Jens Bukh Felix A Rey Steven K H Foung

Data Type

method:	biological activity

Study

name:	Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.
description:	The epitope-specific mAb(s) neutralized HCV subtype 2a JFH1 in focus-forming unit reduction assay. Neutralization potency was calculated to be 0.009 ug/ml IC50.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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