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Title: Binding of autoantibodies to the core region of tissue transglutaminase is a feature of paediatric coeliac disease.
identifier: 1957009
description:
epitope description:C277, H335, D358
antigen name:Protein-glutamine gamma-glutamyltransferase 2
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 22383027
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1025106
landingPage: http://www.iedb.org/assay/1957009
type:
Literature
publicationVenue:
J Pediatr Gastroenterol Nutr
dates:
2012
study type: b cell assays
subject species: Homo sapiens
fullName:
Ross Comerford
Greg Byrne
Conleth Feighery
Jacinta Kelly
method:
ELISA
name:
Binding of autoantibodies to the core region of tissue transglutaminase is a feature of paediatric coeliac disease.
description:
The epitopic residues recognized by serum IgG from adult CD patients were determined by analysis of binding to mutant tTG with single or multiple alanine substitutions at positions C277, H335 or D358. Mutation of any of these residues significantly reduced IgG binding in both adult and pediatric patients.

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