An effector-reduced anti-beta-amyloid (Abeta) antibody with unique abeta binding properties promotes neuroprotection and glial engulfment of Abeta.

Title:

An effector-reduced anti-beta-amyloid (Abeta) antibody with unique abeta binding properties promotes neuroprotection and glial engulfment of Abeta.

Dataset

identifier:	1957016
description:	epitope description:VHHQKLVFFAED antigen name:Amyloid beta A4 protein host organism:Mus musculus antibody name:MABT
aggregation:	instance of dataset
availability:	available
primaryPublications:	22787053

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025108
landingPage:	http://www.iedb.org/assay/1957016

Publication

type:	Literature
publicationVenue:	J Neurosci
dates:	2012

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Oskar Adolfsson Maria Pihlgren Nicolas Toni Yvan Varisco Anna Lucia Buccarello Katia Antoniello Sophie Lohmann Kasia Piorkowska Valerie Gafner Jasvinder K Atwal Janice Maloney Mark Chen Alvin Gogineni Robby M Weimer Deborah L Mortensen Michel Friesenhahn Carole Ho Robert Paul Andrea Pfeifer Andreas Muhs Ryan J Watts

Data Type

method:	ELISA

Study

name:	An effector-reduced anti-beta-amyloid (Abeta) antibody with unique abeta binding properties promotes neuroprotection and glial engulfment of Abeta.
description:	The epitope-specific humanized mAb MABT bound to multiple Aß 1-42 species (monomers, oligomers, and fibers) and bound to Aß 1-40. MABT inhibited aggregation of Aß 1-42 and promoted disassembly of preformed Aß 1-42 aggregates.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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