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Title: Toward a hepatitis C virus vaccine: the structural basis of hepatitis C virus neutralization by AP33, a broadly neutralizing antibody.
identifier: 1957690
description:
epitope description:QLINTNGSWHVN + PYRE(Q1)
antigen name:Genome polyprotein
host organism:Mus musculus BALB/c
antibody name:AP33
aggregation:
instance of dataset
availability:
available
primaryPublications: 22993159
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1025145
landingPage: http://www.iedb.org/assay/1957690
type:
Literature
publicationVenue:
J Virol
dates:
2012
study type: b cell assays
subject species: Hepatitis C virus (isolate Glasgow)
fullName:
Jane A Potter
Ania M Owsianka
Nathan Jeffery
David J Matthews
Zhen-Yong Keck
Patrick Lau
Steven K H Foung
Garry L Taylor
Arvind H Patel
method:
x-ray crystallography
name:
Toward a hepatitis C virus vaccine: the structural basis of hepatitis C virus neutralization by AP33, a broadly neutralizing antibody.
description:
The N-terminal Gln residue is a pyroglutamic acid residue.
The crystal structure of Fab AP33 bound to the epitope was solved by molecular replacement.

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