In vivo and in vitro evidence that cross-reactive antibodies to C-terminus of hypervariable region 1 do not neutralize heterologous hepatitis C virus.

Title:

In vivo and in vitro evidence that cross-reactive antibodies to C-terminus of hypervariable region 1 do not neutralize heterologous hepatitis C virus.

Dataset

identifier:	1959690
description:	epitope description:ASQKIQLI antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:2Aa, 2Ed, 9Dd,11Gb, 18Ie
aggregation:	instance of dataset
availability:	available
primaryPublications:	12163260

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001923
landingPage:	http://www.iedb.org/assay/1959690

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2002

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus

Person

fullName:	Mariko Esumi Yi-Hua Zhou Tetsuya Tanoue Tetsushi Tomoguri Ikuo Hayasaka

Data Type

method:	immunoprecipitation

Study

name:	In vivo and in vitro evidence that cross-reactive antibodies to C-terminus of hypervariable region 1 do not neutralize heterologous hepatitis C virus.
description:	Five of the seven antibodies raised to the epitope partially immunoprecipitated an heterologous hepatitis C virus expressing a hypervariable region 1 differing from the epitopic sequence at residue 30 (I to V).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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