Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate.

Dataset

identifier:	1960413
description:	epitope description:QLYKTCKQAGTCPPDIIPKV antigen name:Minor capsid protein L2 host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	22761884

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1024506
landingPage:	http://www.iedb.org/assay/1960413

Publication

type:	Literature
publicationVenue:	PLoS One
dates:	2012

Dimension

study type:	b cell assays
subject species:	Human papillomavirus type 16

Person

fullName:	Karen Nieto Margit Weghofer Peter Sehr Mirko Ritter Sebastian Sedlmeier Balasubramanyam Karanam Hanna Seitz Martin Mü ller Markus Kellner Markus Hö rer Uwe Michaelis Richard B S Roden Lutz Gissmann Jü rgen A Kleinschmidt

Data Type

method:	biological activity

Study

name:	Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate.
description:	Sera from mice immunized with the adeno-associated virus VLP containing the L2 epitope (17-36) from HPV16 and HPV31 were shown to cross-neutralize the heterologous virus. Neutralization was determined by inhibition of gene transduction by pseudovirions (PsV) containing the gene for gaussia luciferase.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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