Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1960868 |
| description: |
epitope description:V300, M301, K334, P336, F337, S338, T339, Q340, E342, K343, G344, A345, T346, Q347, G349, R350, L351, P372, V379, A382, G383, E384
antigen name:Genome polyprotein
host organism:Mus musculus C57BL/6
antibody name:E111
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23055922 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025160 |
| landingPage: |
http://www.iedb.org/assay/1960868 |
| type: |
Literature
|
| publicationVenue: |
PLoS Pathog
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Dengue virus type 1 strain 16007 |
| fullName: |
S Kyle Austin
Kimberly A Dowd
Bimmi Shrestha
Christopher A Nelson
Melissa A Edeling
Syd Johnson
Theodore C Pierson
Michael S Diamond
Daved H Fremont
|
| method: |
biological activity
|
| name: |
Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope.
|
| description: |
The epitope specific E111 neutralized DENV1 16007 (genotype 2). E111 potently neutralized DENV1 genotypes 2 and 5, and poorly neutralized genotypes 1, 3 and 4. MAb E111 effectively neutralized DENV1 16007 when premixed with the virus before cell attachment or when added after virus attachment to the cell surface. The EC50 values for neutralization were similar at 37ºC or 40ºC over a period of 4.5 h, and only decreased after 22 h suggesting E111 epitopes become exposed for binding with time.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
