Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1960869 |
| description: |
epitope description:V300, M301, K334, P336, F337, S338, T339, Q340, E342, K343, G344, A345, T346, Q347, G349, R350, L351, P372, V379, A382, G383, E384
antigen name:Genome polyprotein
host organism:Mus musculus C57BL/6
antibody name:E111
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23055922 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025160 |
| landingPage: |
http://www.iedb.org/assay/1960869 |
| type: |
Literature
|
| publicationVenue: |
PLoS Pathog
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Dengue virus type 1 strain 16007 |
| fullName: |
S Kyle Austin
Kimberly A Dowd
Bimmi Shrestha
Christopher A Nelson
Melissa A Edeling
Syd Johnson
Theodore C Pierson
Michael S Diamond
Daved H Fremont
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| method: |
biological activity
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| name: |
Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope.
|
| description: |
The epitope specific E111 neutralized DENV1 Nauru/West Pac/1974 (genotype 4) weakly. E111 potently neutralized DENV1 genotypes 2 and 5, and poorly neutralized genotypes 1, 3 and 4. Neutralization by mAb E111 increased after incubation with the virus at 40ºC for 4.5 h compared to 37ºC, suggesting E111 epitopes become exposed for binding with time.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
