Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1960847 |
| description: |
epitope description:V300, M301, K334, P336, F337, S338, T339, Q340, E342, K343, G344, A345, T346, Q347, G349, R350, L351, P372, V379, A382, G383, E384
antigen name:Genome polyprotein
host organism:Mus musculus C57BL/6
antibody name:E111
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23055922 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025160 |
| landingPage: |
http://www.iedb.org/assay/1960847 |
| type: |
Literature
|
| publicationVenue: |
PLoS Pathog
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Dengue virus type 1 strain 16007 |
| fullName: |
S Kyle Austin
Kimberly A Dowd
Bimmi Shrestha
Christopher A Nelson
Melissa A Edeling
Syd Johnson
Theodore C Pierson
Michael S Diamond
Daved H Fremont
|
| method: |
surface plasmon resonance (SPR)
|
| name: |
Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope.
|
| description: |
The epitope specific E111 bound to the DIII domain of DENV1 16007 envelope protein with high affinity. The t 1/2 = 194 sec. Mutation of contact residue T339 to Ser on DIII did not affect E111 affinity, whereas mutation of contact residue A345 to Val decreased affinity to Kd = 1143 nM and t 1/2 = 5.3 sec.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
