Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1960873 |
| description: |
epitope description:V580, M581, K614, P616, F617, S618, S619, Q620, E622, K623, G624, V625, T626, Q627, G629, R630, L631, P652, V659, A662, G663, E664
antigen name:Genome polyprotein
host organism:Mus musculus C57BL/6
antibody name:E111
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23055922 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025160 |
| landingPage: |
http://www.iedb.org/assay/1960873 |
| type: |
Literature
|
| publicationVenue: |
PLoS Pathog
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Dengue virus 1 Nauru/West Pac/1974 |
| fullName: |
S Kyle Austin
Kimberly A Dowd
Bimmi Shrestha
Christopher A Nelson
Melissa A Edeling
Syd Johnson
Theodore C Pierson
Michael S Diamond
Daved H Fremont
|
| method: |
biological activity
|
| name: |
Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope.
|
| description: |
The epitope specific E111 neutralized DENV1 Nauru/West Pac/1974 (genotype 4) weakly. E111 potently neutralized DENV1 genotypes 2 and 5, and poorly neutralized genotypes 1, 3, and 4. Neutralization by mAb E111 increased after incubation with the virus at 40ºC for 4.5 h compared to 37ºC, suggesting E111 epitopes become exposed for binding with time.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
