Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1964480 |
| description: |
epitope description:G147, V148, S149, A150, W166, T168, G169, N171, G172, L173, N200, G202, D203, R205, A206, L207, K235, D238, R239, E240
antigen name:Hemagglutinin
host organism:Homo sapiens
antibody name:CH65
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23175789 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025297 |
| landingPage: |
http://www.iedb.org/assay/1964480 |
| type: |
Literature
|
| publicationVenue: |
Proc Natl Acad Sci U S A
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Influenza A virus (A/Solomon Islands/3/2006(H1N1)) |
| fullName: |
Aaron G Schmidt
Huafeng Xu
Amir R Khan
Timothy O'Donnell
Surender Khurana
Lisa R King
Jody Manischewitz
Hana Golding
Pirada Suphaphiphat
Andrea Carfi
Ethan C Settembre
Philip R Dormitzer
Thomas B Kepler
Ruijun Zhang
M Anthony Moody
Barton F Haynes
Hua-Xin Liao
David E Shaw
Stephen C Harrison
|
| method: |
biological activity
|
| name: |
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
|
| description: |
The epitope was determined in the cited reference: Whittle et al. (2011) Proc Natl Acad Sci USA 108(34): 14216-14221 [PMID: 21825125].
The epitope-specific mAb CH65 neutralized 19 of 23 strains of Influenza A virus tested, as determined in a micro-neutralization assay.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
