Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.

Title:

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.

identifier:	1963908
description:	epitope description:G147, V148, S149, A150, W166, T168, N171, G172, L173, N200, G202, D203, R205, A206, L207, H209, K232, D238 antigen name:Hemagglutinin host organism:Homo sapiens antibody name:CH67
aggregation:	instance of dataset
availability:	available
primaryPublications:	23175789

study type:	b cell assays
subject species:	Influenza A virus (A/Solomon Islands/3/2006(H1N1))

fullName:	Aaron G Schmidt Huafeng Xu Amir R Khan Timothy O'Donnell Surender Khurana Lisa R King Jody Manischewitz Hana Golding Pirada Suphaphiphat Andrea Carfi Ethan C Settembre Philip R Dormitzer Thomas B Kepler Ruijun Zhang M Anthony Moody Barton F Haynes Hua-Xin Liao David E Shaw Stephen C Harrison

method:	biological activity

name:	Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
description:	The epitope residues were calculated from [PDB: 4HKX] as the antigen residues at 4Å atomic distance from the antibody. An additional contact residue Q226 was mismatched to R239 in the GenBank entry. The epitope-specific mAb CH67 neutralized 19 of 23 strains of Influenza A virus tested, as determined in a micro-neutralization assay.

name:	iedb
homePage:	http://www.iedb.org

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