Sculpting humoral immunity through dengue vaccination to enhance protective immunity. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Sculpting humoral immunity through dengue vaccination to enhance protective immunity.

Dataset

identifier:	1964551
description:	epitope description:G106, L107 antigen name:Genome polyprotein host organism:Mus musculus antibody name:23-2
aggregation:	instance of dataset
availability:	available
primaryPublications:	23162552

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025291
landingPage:	http://www.iedb.org/assay/1964551

Publication

type:	Literature
publicationVenue:	Front Immunol
dates:	2012

Dimension

study type:	b cell assays
subject species:	Dengue virus 1

Person

fullName:	Wayne D Crill Holly R Hughes Nicole B Trainor Brent S Davis Matt T Whitney Gwong-Jen J Chang

Data Type

method:	ELISA

Study

name:	Sculpting humoral immunity through dengue vaccination to enhance protective immunity.
description:	Previously characterized monoclonal antibodies were tested for reactivity against wild-type and mutant DENV1 VLPs. Mutations at G160 and L107 caused a greater than 90% reduction in reactivities compared to wild-type, suggesting that these are critical residues in binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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