Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1965259 |
| description: |
epitope description:S153, P155, R194, E195, E197, R237, D238, I369, D374, C375, T377, C378, F379, S381
antigen name:Proprotein convertase subtilisin/kexin type 9
host organism:Mus musculus
antibody name:J16
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
22019884 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025001 |
| landingPage: |
http://www.iedb.org/assay/1965259 |
| type: |
Literature
|
| publicationVenue: |
J Pharmacol Exp Ther
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Hong Liang
Javier Chaparro-Riggers
Pavel Strop
Tao Geng
Janette E Sutton
Daniel Tsai
Lanfang Bai
Yasmina Abdiche
Jeanette Dilley
Jessica Yu
Si Wu
S Michael Chin
Nicole A Lee
Andrea Rossi
John C Lin
Arvind Rajpal
Jaume Pons
David L Shelton
|
| method: |
surface plasmon resonance (SPR)
|
| name: |
Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates.
|
| description: |
Epitope residues were calculated from [PDB: 3SQO] as the antigen residues at 4Å
atomic distance from the antibody.
The epitope specific mAb J16 binds human PCSK9 with high affinity, as determined by biosensor binding assays.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
