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Title: Genetic control of antibody production during collagen-induced arthritis development in heterogeneous stock mice.
identifier: 1962533
description:
epitope description:LVGPRGERGFP + HYL(P4, P11)
antigen name:Collagen alpha-1(II) chain
host organism:Mus musculus
aggregation:
instance of dataset
availability:
available
primaryPublications: 22886420
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1025234
landingPage: http://www.iedb.org/assay/1962533
type:
Literature
publicationVenue:
Arthritis Rheum
dates:
2012
study type: b cell assays
subject species: Homo sapiens
fullName:
Michael Fö
rster
Bruno Raposo
Diana Ekman
Dorota Klaczkowska
Marjan Popovic
Kutty S Nandakumar
Therese Lindvall
Malin Hultqvist
Ivanka Teneva
Martina Johannesson
Emma Ahlqvist
Rikard Holmdahl
method:
ELISA
name:
Genetic control of antibody production during collagen-induced arthritis development in heterogeneous stock mice.
description:
The epitope sequence is from the cited reference: Kraetsch et al. (2001) Eur J Immunol 31: 1666-1673 [PMID: 11385610].
The antibody titers to the epitope were significantly higher in animals with CIA than in healthy animals at all time points. Antibody titers increased over time during CIA. The ELISA plates were coated with the epitope as triple helical peptides. There was an association of the response to the epitope during CIA with the Igh locus on chromosome 12.

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