Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.

Title:

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.

Dataset

identifier:	1962909
description:	epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV antigen name:Amyloid beta A4 protein host organism:Mus musculus APPsw antibody name:A11
aggregation:	instance of dataset
availability:	available
primaryPublications:	22866920

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025190
landingPage:	http://www.iedb.org/assay/1962909

Publication

type:	Literature
publicationVenue:	Mol Neurodegener
dates:	2012

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Suhail Rasool Ricardo Albay 3rd Hilda Martinez-Coria Leonid Breydo Jessica Wu Saskia Milton Sunit Misra Andy Tran Anna Pensalfini Frank Laferla Rakez Kayed Charles G Glabe

Data Type

method:	ELISA

Study

name:	Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.
description:	The epitope sequence was cited in Kayed R. and Glabe CG., Methods Enzymol. 2006 413:326-44 [PMID:17046404]. Serum from epitope-vaccinated animals reacted with the epitope prefibrillar oligomer and fibrils.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.