Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.

Title:

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.

Dataset

identifier:	1962911
description:	epitope description:TYLIHVHIITIYHISIYYIV host organism:Mus musculus APPsw
aggregation:	instance of dataset
availability:	available
primaryPublications:	22866920

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025190
landingPage:	http://www.iedb.org/assay/1962911

Publication

type:	Literature
publicationVenue:	Mol Neurodegener
dates:	2012

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Suhail Rasool Ricardo Albay 3rd Hilda Martinez-Coria Leonid Breydo Jessica Wu Saskia Milton Sunit Misra Andy Tran Anna Pensalfini Frank Laferla Rakez Kayed Charles G Glabe

Data Type

method:	in vivo assay

Study

name:	Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.
description:	Vaccination with the epitope-oligomer improved cognitive function and reduced total plaque load (Abeta burden) in the Tg2576 mouse brains and was associated with a low incidence of micro hemorrhage. Vaccination with the epitope strongly reduces levels of Abeta40 and Abeta42 in brain and decreases anti CD45 reactivity. Activated astrocytes surrounding Abeta plaques are decreased in Tg2576 mice following vaccination.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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