Amino acid residue-specific neutralization and nonneutralization of hepatitis C virus by monoclonal antibodies to the E2 protein.

Title:

Amino acid residue-specific neutralization and nonneutralization of hepatitis C virus by monoclonal antibodies to the E2 protein.

identifier:	1963446
description:	epitope description:NTGWLAGLFYQHK antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:MAbs #8, #41
aggregation:	instance of dataset
availability:	available
primaryPublications:	22973024

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

fullName:	Hongying Duan Alla Kachko Lilin Zhong Evi Struble Shivani Pandey Hailing Yan Christine Harman Maria Luisa Virata-Theimer Lu Deng Zhong Zhao Marian Major Stephen Feinstone Pei Zhang

method:	biological activity

name:	Amino acid residue-specific neutralization and nonneutralization of hepatitis C virus by monoclonal antibodies to the E2 protein.
description:	Two out of 4 epitope-specific mAbs were able to neutralize the infectivity on Huh 7.5 cells of an HCV genotype 1a/2a chimera virus produced by replacing the structural genes of J6/JFH1 with those of the HCV H77 strain. The mAbs were not able to neutralize the genotype 2a virus, J6/JFH1, nor other chimeric viruses 1b/2a and 3a/2a.

name:	iedb
homePage:	http://www.iedb.org

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