Characterization of conformation-dependent prion protein epitopes. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Characterization of conformation-dependent prion protein epitopes.

Dataset

identifier:	1963276
description:	epitope description:Y158, Q189 antigen name:Major prion protein host organism:Mus musculus PrP null antibody name:PRC7
aggregation:	instance of dataset
availability:	available
primaryPublications:	22948149

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025257
landingPage:	http://www.iedb.org/assay/1963276

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2012

Dimension

study type:	b cell assays
subject species:	Cervus canadensis nelsoni

Person

fullName:	Hae-Eun Kang Chu Chun Weng Eri Saijo Vicki Saylor Jifeng Bian Sehun Kim Laylaa Ramos Rachel Angers Katie Langenfeld Vadim Khaychuk Carla Calvi Jason Bartz Nora Hunter Glenn C Telling

Data Type

method:	western blot

Study

name:	Characterization of conformation-dependent prion protein epitopes.
description:	The epitope residues are conserved in mouse and american elk PrP, the sequences that were shuffled to generate the immunogen for the mAb, but with different positions. The positions given in the paper are those relative to the mouse sequence. The epitope-specific mAb reacted with squirrel monkey PrP, which harbors the epitope residues at positions 162 and 193, in Western blot.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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