Antigenic characterization of an intrinsically unstructured protein, Plasmodium falciparum merozoite surface protein 2.

Title:

Antigenic characterization of an intrinsically unstructured protein, Plasmodium falciparum merozoite surface protein 2.

identifier:	1963625
description:	epitope description:FINNAYNMSIRRS antigen name:Merozoite surface antigen 2 host organism:Mus musculus CBA antibody name:6D8
aggregation:	instance of dataset
availability:	available
primaryPublications:	22966050

study type:	b cell assays
subject species:	Plasmodium falciparum 3D7

fullName:	Christopher G Adda Christopher A MacRaild Linda Reiling Kaye Wycherley Michelle J Boyle Vivian Kienzle Paul Masendycz Michael Foley James G Beeson Raymond S Norton Robin F Anders

method:	western blot

name:	Antigenic characterization of an intrinsically unstructured protein, Plasmodium falciparum merozoite surface protein 2.
description:	This epitope sequence is shared by strains 3D7 and FC27 of P. falciparum. The epitope-specific mAb reacted with recombinant MSP2 from 3D7 and FC27 strains, both harboring the epitope, as seen by ELISA, Mass Spectometry and Western blot, but very weakly with parasite-derived FC27 MSP2 and not at all with the 3D7 parasite antigen. The reactivity to FC27 MSP2 antigen was enhanced by reduction, with no effect of reduction on the lack of reactivity to the 3D7 parasite antigen.

name:	iedb
homePage:	http://www.iedb.org

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