Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1963826 |
| description: |
epitope description:G147, V148, S149, A150, W166, T168, N171, G172, L173, N200, G202, D203, R205, A206, L207, H209, K232, D238
antigen name:Hemagglutinin
host organism:Homo sapiens
antibody name:CH67
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23175789 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025297 |
| landingPage: |
http://www.iedb.org/assay/1963826 |
| type: |
Literature
|
| publicationVenue: |
Proc Natl Acad Sci U S A
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Influenza A virus (A/Solomon Islands/3/2006(H1N1)) |
| fullName: |
Aaron G Schmidt
Huafeng Xu
Amir R Khan
Timothy O'Donnell
Surender Khurana
Lisa R King
Jody Manischewitz
Hana Golding
Pirada Suphaphiphat
Andrea Carfi
Ethan C Settembre
Philip R Dormitzer
Thomas B Kepler
Ruijun Zhang
M Anthony Moody
Barton F Haynes
Hua-Xin Liao
David E Shaw
Stephen C Harrison
|
| method: |
x-ray crystallography
|
| name: |
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
|
| description: |
The epitope residues were calculated from [PDB: 4HKX] as the antigen residues at 4Å
atomic distance from the antibody. An additional contact residue Q226 was mismatched to R239 in the GenBank entry.
The epitope of Fab CH67 on the HA ectodomain from Influenza A virus (A/Solomon Islands/3/2006(H1N1)) was determined from the crystal structure of the complex, solved by molecular replacement.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
