Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1969126 |
| description: |
epitope description:A: E103, S104, Q106, D107, V108, L109, L110, E111, W116, K117, Q120, E123, L127, P152; B: K55, I60, N61
antigen name:Interleukin-34
host organism:Homo sapiens
antibody name:Ab1.1
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
22483114 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025007 |
| landingPage: |
http://www.iedb.org/assay/1969126 |
| type: |
Literature
|
| publicationVenue: |
Structure
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Xiaolei Ma
Wei Yu Lin
Yongmei Chen
Scott Stawicki
Kiran Mukhyala
Yan Wu
Flavius Martin
J Fernando Bazan
Melissa A Starovasnik
|
| method: |
surface plasmon resonance (SPR)
|
| name: |
Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.
|
| description: |
The binding kinetics of epitope-specific blocking antibody Ab1.1 for human IL-34 was determined by Octet measurement. Affinity maturation of Ab1 to Ab1.1 improved the affinity from KD = 17 nM to 0.12 nM.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
