Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Immunodominance of antigenic site B over site A of hemagglutinin of recent H3N2 influenza viruses. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025450 |
| landingPage: |
http://www.iedb.org/assay/1969009 |
| type: |
Literature
|
| publicationVenue: |
PLoS One
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Influenza A virus (A/Oklahoma/309/2006(H3N2)) |
| fullName: |
Lyubov Popova
Kenneth Smith
Ann H West
Patrick C Wilson
Judith A James
Linda F Thompson
Gillian M Air
|
| method: |
ELISA
|
| name: |
Immunodominance of antigenic site B over site A of hemagglutinin of recent H3N2 influenza viruses.
|
| description: |
Reactivity (relative Kd) towards WT A/Oklahoma/309/2006 HA protein was determined by direct ELISA. A significative (>30%) reduction was found in presence of mutations HL156-157KS in 6 subjects, KFK158-160GST in 11 subjects, NDQI189-192QEQT in 5 subjects and A196V in one subject, for a total of 11 subjects sensitive to mutations in this antigenic site.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |