Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies.

Title:

Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies.

identifier:	1969157
description:	epitope description:Y310 antigen name:Hemagglutinin glycoprotein host organism:Mus musculus BALB/c antibody name:BH141, BH38, I-29
aggregation:	instance of dataset
availability:	available
primaryPublications:	23300970

study type:	b cell assays
subject species:	Measles virus strain Edmonston-B

fullName:	Patrycja J Lech Gregory J Tobin Ruth Bushnell Emily Gutschenritter Linh D Pham Rebecca Nace Els Verhoeyen Franç ois-Loï c Cosset Claude P Muller Stephen J Russell Peter L Nara

method:	biological activity

name:	Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies.
description:	The mAbs were able to neutralize the WT Edmosnton-B virus infectivity of Vero cells, while mutant viruses where the epitope residue was mutated (Y310C) were resistant to neutralization. The assay was performed with GFP-expressing viruses by assessing the number of GFP-expressing syncytia after virus infection.

name:	iedb
homePage:	http://www.iedb.org

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