Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling.

Title:

Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling.

identifier:	1969169
description:	epitope description:YLSEAVY antigen name:Epithelial discoidin domain-containing receptor 1 host organism:Mus musculus BALB/c antibody name:3G10, 3H10, 7A9
aggregation:	instance of dataset
availability:	available
primaryPublications:	22483115

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Federico Carafoli Marie Cathrin Mayer Kazushige Shiraishi Mira Anguelova Pecheva Lai Yi Chan Ruodan Nan Birgit Leitinger Erhard Hohenester

method:	ELISA

name:	Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling.
description:	The epitope-specific mAbs 3G10, 3H10 and 7A9 bound to the extracellular region of DDR1 with an apparent dissociation constant of approximately 2 nM. Analysis of deletion constructs showed that the mAbs bound to the membrane-proximal DS-like domain (201-369), but not to the membrane-distal DS domain (31-185) containing the collagen binding site.

name:	iedb
homePage:	http://www.iedb.org

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