Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1966210 |
| description: |
epitope description:K147, V149, S159, W167, K170, S173, H197, P200, T201, T203, D204, Q206, S207, L208, Q210, K236, D239, A241, G242
antigen name:Hemagglutinin
host organism:Homo sapiens
antibody name:1F1
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23236279 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025356 |
| landingPage: |
http://www.iedb.org/assay/1966210 |
| type: |
Literature
|
| publicationVenue: |
PLoS Pathog
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Influenza A virus (A/South Carolina/1/1918(H1N1)) |
| fullName: |
Tshidi Tsibane
Damian C Ekiert
Jens C Krause
Osvaldo Martinez
James E Crowe Jr
Ian A Wilson
Christopher F Basler
|
| method: |
surface plasmon resonance (SPR)
|
| name: |
Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses.
|
| description: |
The affinity of epitope-specific 1F1 Fab for the 1918 HA from the influenza A virus (A/New_York/1/18(H1N1)) strain was determined using anti-Penta-HIS tips on the Octet QK platform. The D225G substitution of an epitope residue in this strain reduced the affinity about 360-fold.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
