A plaque-specific antibody clears existing beta-amyloid plaques in Alzheimer's disease mice. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

A plaque-specific antibody clears existing beta-amyloid plaques in Alzheimer's disease mice.

Dataset

identifier:	1966273
description:	epitope description:DAEFR antigen name:Amyloid beta A4 protein host organism:Mus musculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	23217740

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025346
landingPage:	http://www.iedb.org/assay/1966273

Publication

type:	Literature
publicationVenue:	Neuron
dates:	2012

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Ronald B Demattos Jirong Lu Ying Tang Margaret M Racke Cindy A Delong John A Tzaferis Justin T Hole Beth M Forster Peter C McDonnell Feng Liu Robert D Kinley William H Jordan Michael L Hutton

Data Type

method:	in vivo assay

Study

name:	A plaque-specific antibody clears existing beta-amyloid plaques in Alzheimer's disease mice.
description:	Treatment of 9 months old APP mice with the epitope-specific mAb led to significant prevention of A beta deposition in hippocampus and cortex. In contrast, the aged PDAPP mice (expressing human Abeta) treated from 18 to 24 months showed no effect on levels of existing deposited A beta in either the hippocampus or cortex. A dramatic increase in microhemorrhage with treatment with the epitope-specific mAb was observed.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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