The structure of a polyQ-anti-polyQ complex reveals binding according to a linear lattice model. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

The structure of a polyQ-anti-polyQ complex reveals binding according to a linear lattice model.

Dataset

identifier:	1966326
description:	epitope description:GQQQQQQQQQQG host organism:Mus musculus BALB/c antibody name:MW1
aggregation:	instance of dataset
availability:	available
primaryPublications:	17450152

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025018
landingPage:	http://www.iedb.org/assay/1966326

Publication

type:	Literature
publicationVenue:	Nat Struct Mol Biol
dates:	2007

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Pingwei Li Kathryn E Huey-Tubman Tiyu Gao Xiaojun Li Anthony P West Jr Melanie J Bennett Pamela J Bjorkman

Data Type

method:	x-ray crystallography

Study

name:	The structure of a polyQ-anti-polyQ complex reveals binding according to a linear lattice model.
description:	The MW1 Fv-polyQ complex was generated by binding FV to SUMO-10Q, then removing the SUMO protein by protease cleavage, resulting in cocrystals containing the epitope, Gly-(Gln)10-Gly peptide. Two crystal structures with different space groups were solved. This structure was space group P2₁ and the other structure was P2₁2₁2 [PDB: 2OTW]. There are four complexes in the asymmetric unit.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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