Mechanistic study of broadly neutralizing human monoclonal antibodies against dengue virus that target the fusion loop.

Title:

Mechanistic study of broadly neutralizing human monoclonal antibodies against dengue virus that target the fusion loop.

identifier:	1966358
description:	epitope description:W101, G109 antigen name:Genome polyprotein host organism:Homo sapiens antibody name:mAb D11C, mAb 1.6D
aggregation:	instance of dataset
availability:	available
primaryPublications:	23077306

study type:	b cell assays
subject species:	Dengue virus 3

fullName:	Joshua M Costin Elena Zaitseva Kristen M Kahle Cindo O Nicholson Dawne K Rowe Amanda S Graham Lindsey E Bazzone Greg Hogancamp Marielys Figueroa Sierra Rachel H Fong Sung-Tae Yang Li Lin James E Robinson Benjamin J Doranz Leonid V Chernomordik Scott F Michael John S Schieffelin Sharon Isern

method:	biological activity

name:	Mechanistic study of broadly neutralizing human monoclonal antibodies against dengue virus that target the fusion loop.
description:	The epitope-specific mAbs neutralized DENV infection of LLC-MK2 cells. The neutralization activities correlated with a strong inhibition of virus-liposome and intracellular fusion, not virus-cell binding.

name:	iedb
homePage:	http://www.iedb.org

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