Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.

Dataset

identifier:	1966368
description:	epitope description:NEQELLELDKWASLWNWFDITNWLWYIR antigen name:Envelope glycoprotein gp160 host organism:Homo sapiens antibody name:10E8
aggregation:	instance of dataset
availability:	available
primaryPublications:	23151583

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025379
landingPage:	http://www.iedb.org/assay/1966368

Publication

type:	Literature
publicationVenue:	Nature
dates:	2012

Dimension

study type:	b cell assays
subject species:	Human immunodeficiency virus 1

Person

fullName:	Jinghe Huang Gilad Ofek Leo Laub Mark K Louder Nicole A Doria-Rose Nancy S Longo Hiromi Imamichi Robert T Bailer Bimal Chakrabarti Shailendra K Sharma S Munir Alam Tao Wang Yongping Yang Baoshan Zhang Stephen A Migueles Richard Wyatt Barton F Haynes Peter D Kwong John R Mascola Mark Connors

Data Type

method:	x-ray crystallography

Study

name:	Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
description:	The crystal structure of Fab 10E8 bound to the MPER epitope was determined. The MPER peptide is synthesized with RRR added to the N- and C-terminus. There are two complexes in the asymmetric unit.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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