Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.

Dataset

identifier:	1966373
description:	epitope description:NEQELLELDKWASLWNWFDITNWLWYIR antigen name:Envelope glycoprotein gp160 host organism:Homo sapiens antibody name:10E8
aggregation:	instance of dataset
availability:	available
primaryPublications:	23151583

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025379
landingPage:	http://www.iedb.org/assay/1966373

Publication

type:	Literature
publicationVenue:	Nature
dates:	2012

Dimension

study type:	b cell assays
subject species:	Human immunodeficiency virus 1

Person

fullName:	Jinghe Huang Gilad Ofek Leo Laub Mark K Louder Nicole A Doria-Rose Nancy S Longo Hiromi Imamichi Robert T Bailer Bimal Chakrabarti Shailendra K Sharma S Munir Alam Tao Wang Yongping Yang Baoshan Zhang Stephen A Migueles Richard Wyatt Barton F Haynes Peter D Kwong John R Mascola Mark Connors

Data Type

method:	biological activity

Study

name:	Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
description:	The epitope-specific mAb 10E8 neutralized a wide range of clonal variants of a 181-isolate HIV-1 Env pseudovirus panel. MAb 10E8 neutralized 98% of the tested pseudoviruses at an IC50 < 50 µg/ml and 72% at an IC50 < 1 µg/ml. MAb 10E8 neutralized a chimeric C1 virus, which contains the HIV-2 Env and the HIV-1 MPER. Alanine scanning of residues NWFDITNWLWYIR showed that positions N16, W17, F18, T21 and R28 in the epitope sequence were important for neutralization activity.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.