TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice.

Title:

TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice.

identifier:	1966428
description:	epitope description:DAEFRHDSGYEVHHQ antigen name:Amyloid beta A4 protein host organism:Mus musculus C57BL/6
aggregation:	instance of dataset
availability:	available
primaryPublications:	23144170

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Maria Pihlgren Alberto B Silva Rime Madani Valé rie Giriens Ying Waeckerle-Men Antonia Fettelschoss David T Hickman Marí a Pilar Ló pez-Deber Dorin Mlaki Ndao Marija Vukicevic Anna Lucia Buccarello rie Gafner Nathalie Chuard Pedro Reis Kasia Piorkowska Andrea Pfeifer Thomas M Kü ndig Andreas Muhs På l Johansen

method:	antigen inhibition

name:	TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice.
description:	The Aß1-42 peptide inhibited the binding of epitope-immunized serum from binding to the Aß1-42 peptide in a competitive ELISA. Direct ELISAs showed that immunization with a vaccine consisting of a dense array of the epitope on liposomes induced epitope-specific IgG responses totally independent of T-cell help. Independency was confirmed in mice lacking T cells and in mice deficient for MHC class II, CD40L, and CD28. TLR4 and TRIF are required for the induction of epitope-specific IgG response.

name:	iedb
homePage:	http://www.iedb.org

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