Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure. |
| identifier: | 1966607 |
| description: |
epitope description:S115, D116, K117, A120, F121, K139, N140, V144, K145, T166, Q167, V168, E189, D192, I193
antigen name:Toll-like receptor 3
host organism:Homo sapiens
antibody name:Fab12
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
22579623 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025010 |
| landingPage: |
http://www.iedb.org/assay/1966607 |
| type: |
Literature
|
| publicationVenue: |
J Mol Biol
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Jinquan Luo
Galina Obmolova
Thomas J Malia
Sheng-Jiun Wu
Karen E Duffy
James D Marion
Jessica K Bell
Peng Ge
Z Hong Zhou
Alexey Teplyakov
Yonghong Zhao
Roberta J Lamb
Jarrat L Jordan
Lani R San Mateo
Raymond W Sweet
Gary L Gilliland
|
| method: |
biological activity
|
| name: |
Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure.
|
| description: |
The epitope residues were calculated from [PDB: 3ULU] as the antigen residues at 4Å
atomic distance from the antibody.
The epitope-specific mAb12 inhibited TLR3-mediated poly(I:C)-induced signals in the luciferase reporter assay.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |