A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Abeta42 DNA vaccine for Alzheimer disease.

Title:

A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Abeta42 DNA vaccine for Alzheimer disease.

identifier:	1966631
description:	epitope description:DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA antigen name:Amyloid beta A4 protein host organism:Mus musculus C57BL/6 x SJL
aggregation:	instance of dataset
availability:	available
primaryPublications:	23036592

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Doris Lambracht-Washington Bao-xi Qu Min Fu Larry D Anderson Jr Todd N Eagar Olaf Stü ve Roger N Rosenberg

method:	ELISA

name:	A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Abeta42 DNA vaccine for Alzheimer disease.
description:	The epitope sequence was provided in cited reference Qu et al. Arch Neurol 2004 61:1859 [PMID:15596606]. Epitope-specific plasma IgG (both IgG1 and IgG2a) was detected in mice primed with the epitope encoded in pDNA and then boosted with the epitope alone. Reactivity was similar to immunization with the epitope alone given with QuilA and greater than that of immunization with epitope-encoded plasmid alone or that peptide prime, pDNA boost.

name:	iedb
homePage:	http://www.iedb.org

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