A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Abeta42 DNA vaccine for Alzheimer disease.

Title:

A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Abeta42 DNA vaccine for Alzheimer disease.

identifier:	1966635
description:	epitope description:FRHDSGYEVHHQKL antigen name:Amyloid beta A4 protein host organism:Mus musculus C57BL/6 x SJL
aggregation:	instance of dataset
availability:	available
primaryPublications:	23036592

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Doris Lambracht-Washington Bao-xi Qu Min Fu Larry D Anderson Jr Todd N Eagar Olaf Stü ve Roger N Rosenberg

method:	ELISA

name:	A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Abeta42 DNA vaccine for Alzheimer disease.
description:	The epitope sequence was provided in cited reference Qu et al. Arch Neurol 2004 61:1859 [PMID:15596606]. Epitope-specific plasma IgG2a/c was detected in mice primed with the AB1-42 peptide encoded in pDNA and then boosted with the epitope alone. Reactivity was low or non-existent following immunization with AB1-42 alone given with QuilA or with AB1-42 encoded plasmid alone or AB1-42 peptide prime, pDNA boost.

name:	iedb
homePage:	http://www.iedb.org

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