Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | A molecular assembly system for presentation of antigens on the surface of HBc virus-like particles. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1025405 |
| landingPage: |
http://www.iedb.org/assay/1966726 |
| type: |
Literature
|
| publicationVenue: |
Virology
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Influenza A virus (A/chicken/Kurgan/05/2005(H5N1)) |
| fullName: |
Elena A Blokhina
Victor V Kuprianov
Ludmila A Stepanova
Ludmila M Tsybalova
Oleg I Kiselev
Nikolai V Ravin
Konstantin G Skryabin
|
| method: |
ELISA
|
| name: |
A molecular assembly system for presentation of antigens on the surface of HBc virus-like particles.
|
| description: |
A strong immune response developed in mice that were immunized with the 3MP HBc formulation,even after the first immunization. The antibody titer in the serum increased further after the second immunization.The 3MP protein was less immunogenic when it was not linked to HBc. Binding of the epitope to the HBc carrier greatly enhanced immunogenicity and 3 epitope copies raised a faster response than 2 copies. In a separate experiment, the administration of IL-2 on separate HBc carrier induced a strong response.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |