Design of a heterotetravalent synthetic allergen that reflects epitope heterogeneity and IgE antibody variability to study mast cell degranulation.

Title:

Design of a heterotetravalent synthetic allergen that reflects epitope heterogeneity and IgE antibody variability to study mast cell degranulation.

Dataset

identifier:	1966831
description:	epitope description:2,4-dinitrophenol host organism:Mus musculus antibody name:IgE^DNP
aggregation:	instance of dataset
availability:	available
primaryPublications:	23050868

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025387
landingPage:	http://www.iedb.org/assay/1966831

Publication

type:	Literature
publicationVenue:	Biochem J
dates:	2013

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Michael W Handlogten Tanyel Kiziltepe Basar Bilgicer

Data Type

method:	biological activity

Study

name:	Design of a heterotetravalent synthetic allergen that reflects epitope heterogeneity and IgE antibody variability to study mast cell degranulation.
description:	DNP-Pro linked to a lysine MAP display very weakly induced degranulation of epitope-specific mAb-sensitized mast cell line RBL, while the combination on the MAP of two molecules of two different haptens that are weak inducers and co-sensitization of the mast cells with mAbs against both epitopes synergistically augmented the response.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.