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Title: Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis.
identifier: 1966845
description:
epitope description:TPRVERNGHSVFLAPYGWMVK + GLUC(N7)
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 23167575
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1025349
landingPage: http://www.iedb.org/assay/1966845
type:
Literature
publicationVenue:
J Med Chem
dates:
2012
study type: b cell assays
subject species:
fullName:
Shashank Pandey
Maria C Alcaro
Mario Scrima
Elisa Peroni
Ilaria Paolini
Sara Di Marino
Francesca Barbetti
Alfonso Carotenuto
Ettore Novellino
Anna Maria Papini
Anna Maria D'Ursi
Paolo Rovero
method:
ELISA
name:
Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis.
description:
The epitope is a previously characterized artificial glycopeptide with capacity to react with multiple-sclerosis patients' sera, and shown to display sequence and structural homology to human myelin proteins.
Significant higher titers to the epitope were obtained in 50 MS patients' sera than in 50 normal blood donors and 30 other neurological diseases patients.

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